COVID-19-induced anosmia associated with olfactory bulb atrophy.
Identifieur interne : 000091 ( Main/Exploration ); précédent : 000090; suivant : 000092COVID-19-induced anosmia associated with olfactory bulb atrophy.
Auteurs : Andrew Chiu [États-Unis] ; Nancy Fischbein [États-Unis] ; Max Wintermark [États-Unis] ; Greg Zaharchuk [États-Unis] ; Paul T. Yun [États-Unis] ; Michael Zeineh [États-Unis]Source :
- Neuroradiology [ 1432-1920 ] ; 2021.
Abstract
As the global COVID-19 pandemic evolves, our knowledge of the respiratory and non-respiratory symptoms continues to grow. One such symptom, anosmia, may be a neurologic marker of coronavirus infection and the initial presentation of infected patients. Because this symptom is not routinely investigated by imaging, there is conflicting literature on neuroimaging abnormalities related to COVID-19-related anosmia. We present a novel case of COVID-19 anosmia with definitive olfactory bulb atrophy compared with pre-COVID imaging. The patient had prior MR imaging related to a history of prolactinoma that provided baseline volumes of her olfactory bulbs. After a positive diagnosis of COVID-19 and approximately 2 months duration of anosmia, an MRI was performed that showed clear interval olfactory bulb atrophy. This diagnostic finding is of prognostic importance and indicates that the olfactory entry point to the brain should be further investigated to improve our understanding of COVID infectious pathophysiology.
DOI: 10.1007/s00234-020-02554-1
PubMed: 32930820
PubMed Central: PMC7490479
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">COVID-19-induced anosmia associated with olfactory bulb atrophy.</title><author><name sortKey="Chiu, Andrew" sort="Chiu, Andrew" uniqKey="Chiu A" first="Andrew" last="Chiu">Andrew Chiu</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105, USA. ac3@stanford.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105</wicri:regionArea><orgName type="university">Université Stanford</orgName><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fischbein, Nancy" sort="Fischbein, Nancy" uniqKey="Fischbein N" first="Nancy" last="Fischbein">Nancy Fischbein</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105</wicri:regionArea><orgName type="university">Université Stanford</orgName><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wintermark, Max" sort="Wintermark, Max" uniqKey="Wintermark M" first="Max" last="Wintermark">Max Wintermark</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105</wicri:regionArea><orgName type="university">Université Stanford</orgName><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zaharchuk, Greg" sort="Zaharchuk, Greg" uniqKey="Zaharchuk G" first="Greg" last="Zaharchuk">Greg Zaharchuk</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105</wicri:regionArea><orgName type="university">Université Stanford</orgName><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Yun, Paul T" sort="Yun, Paul T" uniqKey="Yun P" first="Paul T" last="Yun">Paul T. Yun</name><affiliation wicri:level="1"><nlm:affiliation>Menlo Medical Clinic Stanford HealthCare, 321 Middlefield Road, 1st Floor, Menlo Park, CA, 94205, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Menlo Medical Clinic Stanford HealthCare, 321 Middlefield Road, 1st Floor, Menlo Park, CA, 94205</wicri:regionArea><wicri:noRegion>94205</wicri:noRegion></affiliation></author><author><name sortKey="Zeineh, Michael" sort="Zeineh, Michael" uniqKey="Zeineh M" first="Michael" last="Zeineh">Michael Zeineh</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105</wicri:regionArea><orgName type="university">Université Stanford</orgName><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:32930820</idno><idno type="pmid">32930820</idno><idno type="doi">10.1007/s00234-020-02554-1</idno><idno type="pmc">PMC7490479</idno><idno type="wicri:Area/Main/Corpus">000317</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000317</idno><idno type="wicri:Area/Main/Curation">000317</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000317</idno><idno type="wicri:Area/Main/Exploration">000317</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">COVID-19-induced anosmia associated with olfactory bulb atrophy.</title><author><name sortKey="Chiu, Andrew" sort="Chiu, Andrew" uniqKey="Chiu A" first="Andrew" last="Chiu">Andrew Chiu</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105, USA. ac3@stanford.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105</wicri:regionArea><orgName type="university">Université Stanford</orgName><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fischbein, Nancy" sort="Fischbein, Nancy" uniqKey="Fischbein N" first="Nancy" last="Fischbein">Nancy Fischbein</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105</wicri:regionArea><orgName type="university">Université Stanford</orgName><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wintermark, Max" sort="Wintermark, Max" uniqKey="Wintermark M" first="Max" last="Wintermark">Max Wintermark</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105</wicri:regionArea><orgName type="university">Université Stanford</orgName><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zaharchuk, Greg" sort="Zaharchuk, Greg" uniqKey="Zaharchuk G" first="Greg" last="Zaharchuk">Greg Zaharchuk</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105</wicri:regionArea><orgName type="university">Université Stanford</orgName><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Yun, Paul T" sort="Yun, Paul T" uniqKey="Yun P" first="Paul T" last="Yun">Paul T. Yun</name><affiliation wicri:level="1"><nlm:affiliation>Menlo Medical Clinic Stanford HealthCare, 321 Middlefield Road, 1st Floor, Menlo Park, CA, 94205, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Menlo Medical Clinic Stanford HealthCare, 321 Middlefield Road, 1st Floor, Menlo Park, CA, 94205</wicri:regionArea><wicri:noRegion>94205</wicri:noRegion></affiliation></author><author><name sortKey="Zeineh, Michael" sort="Zeineh, Michael" uniqKey="Zeineh M" first="Michael" last="Zeineh">Michael Zeineh</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105</wicri:regionArea><orgName type="university">Université Stanford</orgName><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Neuroradiology</title><idno type="eISSN">1432-1920</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">As the global COVID-19 pandemic evolves, our knowledge of the respiratory and non-respiratory symptoms continues to grow. One such symptom, anosmia, may be a neurologic marker of coronavirus infection and the initial presentation of infected patients. Because this symptom is not routinely investigated by imaging, there is conflicting literature on neuroimaging abnormalities related to COVID-19-related anosmia. We present a novel case of COVID-19 anosmia with definitive olfactory bulb atrophy compared with pre-COVID imaging. The patient had prior MR imaging related to a history of prolactinoma that provided baseline volumes of her olfactory bulbs. After a positive diagnosis of COVID-19 and approximately 2 months duration of anosmia, an MRI was performed that showed clear interval olfactory bulb atrophy. This diagnostic finding is of prognostic importance and indicates that the olfactory entry point to the brain should be further investigated to improve our understanding of COVID infectious pathophysiology.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32930820</PMID><DateRevised><Year>2021</Year><Month>01</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1920</ISSN><JournalIssue CitedMedium="Internet"><Volume>63</Volume><Issue>1</Issue><PubDate><Year>2021</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Neuroradiology</Title><ISOAbbreviation>Neuroradiology</ISOAbbreviation></Journal><ArticleTitle>COVID-19-induced anosmia associated with olfactory bulb atrophy.</ArticleTitle><Pagination><MedlinePgn>147-148</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00234-020-02554-1</ELocationID><Abstract><AbstractText>As the global COVID-19 pandemic evolves, our knowledge of the respiratory and non-respiratory symptoms continues to grow. One such symptom, anosmia, may be a neurologic marker of coronavirus infection and the initial presentation of infected patients. Because this symptom is not routinely investigated by imaging, there is conflicting literature on neuroimaging abnormalities related to COVID-19-related anosmia. We present a novel case of COVID-19 anosmia with definitive olfactory bulb atrophy compared with pre-COVID imaging. The patient had prior MR imaging related to a history of prolactinoma that provided baseline volumes of her olfactory bulbs. After a positive diagnosis of COVID-19 and approximately 2 months duration of anosmia, an MRI was performed that showed clear interval olfactory bulb atrophy. This diagnostic finding is of prognostic importance and indicates that the olfactory entry point to the brain should be further investigated to improve our understanding of COVID infectious pathophysiology.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chiu</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-1900-9561</Identifier><AffiliationInfo><Affiliation>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105, USA. ac3@stanford.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fischbein</LastName><ForeName>Nancy</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wintermark</LastName><ForeName>Max</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zaharchuk</LastName><ForeName>Greg</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yun</LastName><ForeName>Paul T</ForeName><Initials>PT</Initials><AffiliationInfo><Affiliation>Menlo Medical Clinic Stanford HealthCare, 321 Middlefield Road, 1st Floor, Menlo Park, CA, 94205, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeineh</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Drive, Room S047, Stanford, CA, 94305-5105, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Neuroradiology</MedlineTA><NlmUniqueID>1302751</NlmUniqueID><ISSNLinking>0028-3940</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anosmia</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Olfactory bulb</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>09</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>15</Day><Hour>12</Hour><Minute>14</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32930820</ArticleId><ArticleId IdType="doi">10.1007/s00234-020-02554-1</ArticleId><ArticleId IdType="pii">10.1007/s00234-020-02554-1</ArticleId><ArticleId IdType="pmc">PMC7490479</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Buschhüter D, Smitka M, Puschmann S, Gerber JC, Witt M, Abolmaali ND, Hummel T (2008) Correlation between olfactory bulb volume and olfactory function. Neuroimage 42(2):498–502</Citation><ArticleIdList><ArticleId IdType="doi">10.1016/j.neuroimage.2008.05.004</ArticleId></ArticleIdList></Reference><Reference><Citation>Rombaux P, Mouraux A, Bertrand B, Nicolas G, Duprez T, Hummel T (2006) Olfactory function and olfactory bulb volume in patients with postinfectious olfactory loss. Laryngoscope 116:436–439</Citation><ArticleIdList><ArticleId IdType="doi">10.1097/01.MLG.0000195291.36641.1E</ArticleId></ArticleIdList></Reference><Reference><Citation>Yao L, Yi X, Pinto JM, Yuan X, Guo Y, Liu Y, Wei Y (2018) Olfactory cortex and olfactory bulb volume alterations in patients with post-infectious olfactory loss. Brain Imaging Behav 12:1355–1362</Citation><ArticleIdList><ArticleId IdType="doi">10.1007/s11682-017-9807-7</ArticleId></ArticleIdList></Reference><Reference><Citation>Brann DH, Tsukahara T, Weinreb C et al (2020) Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. BioRxiv published online May 18. https://doi.org/10.1101/2020.03.25.009084(preprint)</Citation></Reference><Reference><Citation>Politi LS, Salsano E, Grimaldi M (2020) Magnetic resonance imaging alteration of the brain in a patient with coronavirus disease 2019 (COVID-19) and anosmia. JAMA Neurol published online May 29. https://doi.org/10.1001/jamaneurol.2020.2125</Citation></Reference><Reference><Citation>Chung MS, Choi WR, Jeong HY, Lee JH, Kim JH (2018) MR Imaging-based evaluations of olfactory bulb atrophy in patients with olfactory dysfunction. AJNR Am J Neuroradiol 39(3):532–537</Citation><ArticleIdList><ArticleId IdType="doi">10.3174/ajnr.A5491</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Stanford (Californie)</li></settlement><orgName><li>Université Stanford</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Chiu, Andrew" sort="Chiu, Andrew" uniqKey="Chiu A" first="Andrew" last="Chiu">Andrew Chiu</name></region><name sortKey="Fischbein, Nancy" sort="Fischbein, Nancy" uniqKey="Fischbein N" first="Nancy" last="Fischbein">Nancy Fischbein</name><name sortKey="Wintermark, Max" sort="Wintermark, Max" uniqKey="Wintermark M" first="Max" last="Wintermark">Max Wintermark</name><name sortKey="Yun, Paul T" sort="Yun, Paul T" uniqKey="Yun P" first="Paul T" last="Yun">Paul T. Yun</name><name sortKey="Zaharchuk, Greg" sort="Zaharchuk, Greg" uniqKey="Zaharchuk G" first="Greg" last="Zaharchuk">Greg Zaharchuk</name><name sortKey="Zeineh, Michael" sort="Zeineh, Michael" uniqKey="Zeineh M" first="Michael" last="Zeineh">Michael Zeineh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidStanfordV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000091 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000091 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidStanfordV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32930820
|texte= COVID-19-induced anosmia associated with olfactory bulb atrophy.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32930820" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidStanfordV1
| This area was generated with Dilib version V0.6.38. |  |